Belle Mead Compounding Pharmacy is the leading formulation specialist for ketamine nose spray, being used for both pain and as an alternative therapy for depression. This dosage method may provide quick relief for difficult to treat depression
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The nose has nerve fibers within its cavity that directly connects to the brain stem, thus bypassing the illusive blood brain barrier. The tight cell junctions stops most drugs delivered via the bloodstream from the brain. This system also prevents harmful pathogens out as a protective mechanism. However; delivering the drug via the nasal cavity is proven to be a dependable method for administering many useful drugs, including ketamine, oxytocin, HCG, fentanyl, flumazenil, vitamin b12, sermorelin, and many other large peptide analogs.
Specifically regarding ketamine for use as an anti-depressant and for effects of ketamine in the brain is to block the NMDA [N-methyl-d-aspartate] glutamate receptor resulting in a fast response time. Belle Compounding pharmacy can provide the ketamine nose spray in any strength, but keep in mind the drugs solubility is limited at 200mg/ml. It is important to keep this strength at room temperature, to prevent the drug from precipitating out of solution. We use preserved water in our formulation, so the risk of bacterial contamination is minimal. Most common is a 100mg/ml concentration. Talk to your doctor to discuss the dosing. Many times one to two doses will provide a remarkable turnaround from our discussions with patients.
While many antidepressants are associated with numerous side effects, ketamine seems to have a very safe profile with few side effects. Also the 2 to 3 times a week schedule provides a convenient, discreet dosage easy to follow. Important in depression.